1.Brush and floss your teeth. 2.Dry your teeth with a tissue. 3.Twist the bottom of the pen clockwise(to the right) until a little gel flows from the gel chamber on to the brush. For first use you may need more twisting. 4.Smile wide keeping lips away from your teeth. 5.Use even brush strokes to apply a thin layer of gel to each tooth. Do NOT apply gel to the gums. 6.Relax your lips after 30 seconds. 7.Avoid eating or drinking for 30 minutes after treatment. Use twice daily until your teeth have reached your desired shade of white. Be sure to replace the lid, to keep the serum from drying out. Store in a cool place preferably refrigerate.